Motif ID: TFAP2{A,C}.p2

Z-value: 1.214


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TFAP2Achr6_-_104197860.386.4e-02Click!
TFAP2Cchr20_+_552043070.096.8e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_80679897 4.030 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr8_-_48650683 3.552 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_95007139 2.852 NM_001178096
NM_001993
 F3

coagulation factor III (thromboplastin, tissue factor)

chr4_+_4861371 2.109 NM_002448
 MSX1
msh homeobox 1
chr8_-_48650703 2.005 NM_005195
 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_41328002 1.953 NM_133467
 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr20_+_55966440 1.894 NM_017495
NM_183425
 RBM38

RNA binding motif protein 38

chr4_+_139936938 1.860 NM_012118
 CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr6_-_143266283 1.841 NM_006734
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr19_+_45251933 1.764 NM_005178
 BCL3
B-cell CLL/lymphoma 3
chr21_-_35987144 1.736 NM_004414
 RCAN1
regulator of calcineurin 1
chr9_-_38069082 1.643 SHB
Src homology 2 domain containing adaptor protein B
chr1_-_41328019 1.619 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr15_+_67358194 1.543 NM_005902
 SMAD3
SMAD family member 3
chr9_-_140196702 1.497 NM_001004354
 NRARP
NOTCH-regulated ankyrin repeat protein
chr16_+_29817810 1.449 NM_001042539
NM_002383
 MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr18_+_77155927 1.434 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr20_+_6748744 1.433 NM_001200
 BMP2
bone morphogenetic protein 2
chr17_-_73874056 1.426 TRIM47
tripartite motif containing 47
chr11_+_43963809 1.398 NM_001145033
 C11orf96
chromosome 11 open reading frame 96

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 79 entries
enrichment   p-value GO term description
1.45 2.54e-02 GO:0000226 microtubule cytoskeleton organization
1.40 2.40e-02 GO:0044087 regulation of cellular component biogenesis
1.39 2.52e-03 GO:0030036 actin cytoskeleton organization
1.35 2.69e-06 GO:0007010 cytoskeleton organization
1.35 6.22e-04 GO:0051301 cell division
1.34 1.64e-02 GO:0030029 actin filament-based process
1.33 5.94e-04 GO:0007264 small GTPase mediated signal transduction
1.33 4.97e-02 GO:0001568 blood vessel development
1.30 8.93e-04 GO:0072358 cardiovascular system development
1.30 8.93e-04 GO:0072359 circulatory system development
1.30 1.47e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.29 2.86e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.29 2.38e-02 GO:0006886 intracellular protein transport
1.26 1.50e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.24 1.49e-11 GO:0006996 organelle organization
1.23 1.83e-06 GO:0051649 establishment of localization in cell
1.23 6.23e-05 GO:0022008 neurogenesis
1.23 8.28e-04 GO:0051128 regulation of cellular component organization
1.23 1.12e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.23 1.65e-02 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
1.52 1.30e-02 GO:0005925 focal adhesion
1.49 2.15e-02 GO:0005924 cell-substrate adherens junction
1.48 2.23e-02 GO:0030055 cell-substrate junction
1.43 3.78e-03 GO:0070161 anchoring junction
1.43 7.96e-03 GO:0005912 adherens junction
1.38 1.42e-02 GO:0031252 cell leading edge
1.34 9.09e-03 GO:0016323 basolateral plasma membrane
1.28 1.65e-02 GO:0005815 microtubule organizing center
1.28 4.77e-02 GO:0015629 actin cytoskeleton
1.27 2.01e-02 GO:0048471 perinuclear region of cytoplasm
1.24 3.90e-04 GO:0015630 microtubule cytoskeleton
1.22 4.09e-14 GO:0005829 cytosol
1.15 8.66e-06 GO:0044428 nuclear part
1.15 8.75e-05 GO:0031981 nuclear lumen
1.14 3.39e-22 GO:0044444 cytoplasmic part
1.13 5.82e-06 GO:0043228 non-membrane-bounded organelle
1.13 5.82e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.13 7.61e-05 GO:0031974 membrane-enclosed lumen
1.13 1.08e-04 GO:0070013 intracellular organelle lumen
1.13 1.92e-04 GO:0043233 organelle lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
1.30 5.14e-04 GO:0004674 protein serine/threonine kinase activity
1.27 1.64e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.27 3.16e-03 GO:0030695 GTPase regulator activity
1.25 1.56e-05 GO:0016301 kinase activity
1.25 1.99e-03 GO:0008092 cytoskeletal protein binding
1.24 6.54e-05 GO:0019899 enzyme binding
1.24 1.64e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.24 1.03e-03 GO:0004672 protein kinase activity
1.22 4.71e-05 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.19 1.44e-06 GO:0030554 adenyl nucleotide binding
1.18 6.30e-06 GO:0032559 adenyl ribonucleotide binding
1.17 3.34e-05 GO:0005524 ATP binding
1.16 4.06e-06 GO:0017076 purine nucleotide binding
1.16 1.58e-05 GO:0032553 ribonucleotide binding
1.16 1.58e-05 GO:0032555 purine ribonucleotide binding
1.16 6.43e-05 GO:0016740 transferase activity
1.15 1.47e-06 GO:0000166 nucleotide binding
1.15 3.00e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.14 1.04e-31 GO:0005515 protein binding
1.08 2.51e-04 GO:0003824 catalytic activity